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. 2021 Sep 20;30(6):821–835. doi: 10.1007/s11248-021-00285-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Myh6-Cre targets some other organs outside the heart and affects the expression of endogenous Myh6 in heart. a tdTomato was detected in some other organs from the adult Myh6-Cre/ + ;R26-tdTomato/ + mice at P8W. 3 mouse samples were examined. b ECG analyses of the P8W hearts with indicated genotypes. n = 6 mice per group. LVESD, left ventricular end-systolic dimension; LVEDD, left ventricular end-diastolic dimension; ESV, end-systolic volume; EDV, end-diastolic volume; EF, ejection fraction; FS, fractional shortening. c Whole bodies of the mice with indicated genotypes at P8W. d Whole-mount view of the hearts with indicated genotypes at P8W. e The relative heart weight was increased in the Myh6-Cre/Cre mice at P8W. HW, heart weight. BW, body weight. f HE staining shows the thinner left ventricular wall and ventricular septum in the hearts of Myh6-Cre/Cre mice at P8W. g WGA staining on heart sections. h The expression level of Myh6 in the adult hearts at P8W. n = 3 mice per group in (c–h). White scale bars, 5 mm; Black scale bars, 2 mm; Red scale bars, 200 µm; Yellow scale bars, 100 µm. NS, non-significant; *p < 0.05; ***p < 0.001