Fig. 1. Survival rates and morphologic changes in liver, intestine, and lung tissues, in late sepsis stage (day #6).

A Survival rates of CLP sepsis mice treated with the DE or the ES method comparing with the control group at day 6 after CLP operations. Although there was no significant difference between the DE and the ES group (p = 0.051), the DE has the greatest survival benefits compared with other groups. B Mice in sepsis groups showed more leukocyte infiltration and hydropic degeneration in liver tissues, in addition, severe inflammatory cells infiltration and microvilli damages were found in intestine tissues, and more inflammatory cells infiltration were found in lung tissues. The DE treatment presented alleviated pathological changes than the ES treatment. DE de-escalation. ES escalation. N = 10 per experimental group and N = 5 in sham group.