Fig. 2. De-escalation strategy alleviates organ injuries in the late sepsis stage.

A–D The serum levels of the AST, creatine, ALT, and LDH were measured with an ELISA kit in all groups (n = 17). The levels of blood chemistries were lower in the DE group than those in the ES group (p < 0.01). However, those were extremely higher in the control group though there were only 2 of 10 left on day 6. DE de-escalation. ES escalation.