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. 2021 Nov 10;12:6486. doi: 10.1038/s41467-021-26536-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Liver follistatin (FST) secretion is regulated by GCKR-GCK, which is stimulated by glucagon and inhibited by insulin. Elevated follistatin may attenuate insulin-inhibited lipolysis in the adipocytes and mediate adipose tissue insulin resistance and free fatty acid (FFA) release, which ultimately contributes to T2D and NAFLD risk.