Table 4.
Incidence of diabetes in relation to quartiles of follistatin in the IMI-DIRECT-METSIM cohort. The relationship between follistatin levels in plasma and incidence of diabetes during the follow up was explored in 1079 individuals, and fully-adjusted association study was performed in 883 individuals.
| Q1 | Q2 | Q3 | Q4 | p for trend | HR per SD | |
|---|---|---|---|---|---|---|
| Number of participants | 270 | 270 | 269 | 270 | ||
| Incidence of diabetes n (n per 1000 p-y) | 10 (9.26) | 13 (12.04) | 11 (10.22) | 19 (17.59) | ||
| Follistatin (NPX) | 2664.94 ± 343.49 | 3447.24 ± 205.82 | 4194.21 ± 258.59 | 5725.14 ± 1163.54 | ||
| Model 1 HR | 1 | 1.69 (0.80–3.58) | 1.49 (0.70–3.22) | 2.61** (1.29–5.30) | 0.011 | 1.35** (1.13–1.61) |
| Model 2 HR | 1 | 1.12 (0.48–2.60) | 1.19 (0.52–2.75) | 2.25* (1.04–4.86) | 0.029 | 1.28** (1.075–1.524) |
| Model 3 HR | 1 | 1.13 (0.49–2.62) | 1.23 (0.53–2.86) | 2.34* (1.07–5.101) | 0.0237 | 1.31** (1.09–1.58) |
Model 1: Adjusted for age (n = 1079).
Model 2: Adjusted for age, BMI, physical activity, alcohol intake, fiber intake, LDL, HDL cholesterol, fasting glucose (n = 883).
Model 3: Model 2 and CRP (n = 883).
HR hazard ratio. *p < 0.05, **p < 0.01