Table 3.
FAT and FW group comparisons *.
| Covariates: age, sex, motion | Covariates: age, sex, motion, CSF volume | Covariates: age, sex, motion, WM volume | |
|---|---|---|---|
| FAT | |||
| F-test | 45% of the WM skeleton | 24% of the WM skeleton | 27% of the WM skeleton |
| 22q-del versus HC | 22q-del > HC: 24% | 22q-del > HC: – | 22q-del > HC: 1,5% |
| 22q-del < HC: – | 22q-del < HC: – | 22q-del < HC: – | |
| 22q-dup versus HC | 22q-dup > HC: – | 22q-dup > HC: – | 22q-dup > HC: – |
| 22q-dup < HC: 8% | 22q-dup < HC: 23% | 22q-dup < HC: 7% | |
| 22q-del versus 22q-dup | 22q-del > 22q-dup: 54% | 22q-del > 22q-dup: 40% | 22q-del > 22q-dup: 35% |
| 22q-del < 22q-dup: – | 22q-del < 22q-dup: – | 22q-del < 22q-dup: – | |
| FW | |||
| F-test | 72% of the WM skeleton | 63% of the WM skeleton | 55% of the WM skeleton |
| 22q-del versus HC | 22q-del > HC: – | 22q-del > HC: – | 22q-del > HC: – |
| 22q-del < HC: 49% | 22q-del < HC: 3% | 22q-del < HC: – | |
| 22q-dup versus HC | 22q-dup > HC: 59% | 22q-dup > HC: 60% | 22q-dup > HC: 60% |
| 22q-dup < HC: – | 22q-dup < HC: – | 22q-dup < HC: – | |
| 22q-del versus 22q-dup | 22q-del > 22q-dup: – | 22q-del > 22q-dup: – | 22q-del > 22q-dup: – |
| 22q-del < 22q-dup: 76% | 22q-del < 22q-dup: 69% | 22q-del < 22q-dup: 60% |
CSF cerebrospinal fluid, FAT fractional anisotropy of cellular tissue, FW extracellular free-water, HC healthy controls, WM white matter, 22q-del 22q11.2 deletion carriers, 22q-dup 22q11.2 duplication carriers.
*All group comparisons were conducted utilizing non-parametric voxel-wise permutation tests for each voxel on the WM skeleton in FSL’s Randomize [81]. We tested data against a null distribution generated with 5000 permutations for each contrast using threshold-free cluster enhancement [82] and family wise error correction at a significance level of p < 0.05.