Table 4.
F1, F2, and Fiso group comparisons*.
| Covariates: age, sex, motion | Covariates: age, sex, motion, CSF volume | Covariates: age, sex, motion, WM volume | |
|---|---|---|---|
| F1 | |||
| F-test | 36% of the WM skeleton | 32% of the WM skeleton | 14% of the WM skeleton |
| 22q-del versus HC | 22q-del > HC: 8% | 22q-del > HC: – | 22q-del > HC: – |
| 22q-del < HC: – | 22q-del < HC: – | 22q-del < HC: – | |
| 22q-dup versus HC | 22q-dup > HC: – | 22q-dup > HC: – | 22q-dup > HC: – |
| 22q-dup < HC: 26% | 22q-dup < HC: 29% | 22q-dup < HC: 21% | |
| 22q-del versus 22q-dup | 22q-del > 22q-dup: 43% | 22q-del > 22q-dup: 31% | 22q-del > 22q-dup: 21% |
| 22q-del < 22q-dup: – | 22q-del < 22q-dup: – | 22q-del < 22q-dup: – | |
| F2 | |||
| F-test | 40% of the WM skeleton | 26% of the WM skeleton | 23% of the WM skeleton |
| 22q-del versus HC | 22q-del > HC: 28% | 22q-del > HC: 12% | 22q-del > HC: 2% |
| 22q-del < HC: – | 22q-del < HC: – | 22q-del < HC: – | |
| 22q-dup versus HC | 22q-dup > HC: – | 22q-dup > HC: – | 22q-dup > HC: – |
| 22q-dup < HC: 21% | 22q-dup < HC: 21% | 22q-dup < HC: 19% | |
| 22q-del versus 22q-dup | 22q-del > 22q-dup: 46% | 22q-del > 22q-dup: 34% | 22q-del > 22q-dup: 28% |
| 22q-del < 22q-dup: – | 22q-del < 22q-dup: – | 22q-del < 22q-dup: – | |
| Fiso | |||
| F-test | 66% of the WM skeleton | 55% of the WM skeleton | 50% of the WM skeleton |
| 22q-del versus HC | 22q-del > HC: – | 22q-del > HC: – | 22q-del > HC: – |
| 22q-del < HC: 49% | 22q-del < HC: 18% | 22q-del < HC: 12% | |
| 22q-dup versus HC | 22q-dup > HC: 48% | 22q-dup > HC: 52% | 22q-dup > HC: 47% |
| 22q-dup < HC: – | 22q-dup < HC: – | 22q-dup < HC: – | |
| 22q-del versus 22q-dup | 22q-del > 22q-dup: – | 22q-del > 22q-dup: – | 22q-del > 22q-dup: – |
| 22q-del < 22q-dup: 72% | 22q-del < 22q-dup: 64% | 22q-del < 22q-dup: 47% |
CSF cerebrospinal fluid, F1 fractional volume of primary fiber population, F2 fractional volume of secondary fiber population, Fiso fractional volume of the isotropic compartment, HC healthy controls, WM white matter, 22q-del 22q11.2 deletion carriers, 22q-dup 22q11.2 duplication carriers.
*All group comparisons were conducted utilizing non-parametric voxel-wise permutation tests for each voxel on the WM skeleton in FSL’s Randomize [81]. We tested data against a null distribution generated with 5000 permutations for each contrast using threshold-free cluster enhancement [82] and family wise error correction at a significance level of p < 0.05.