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. 2021 Oct 28;8:766486. doi: 10.3389/fmed.2021.766486

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Copyright © 2021 Bussolari, Palumbo, Fominsky, Nardelli, De Lorenzo, Vitali, De Cobelli, Rovere-Querini and Scandroglio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Computed tomography (CT) axial scans (lung parenchyma windowing) acquired, respectively, immediately before (A), 27 (B) and 111 days (C) after the start of nintedanib, demonstrating progressive improvement of lung parenchyma and significant reduction of residual lung damage. At each time point, the axial CT image most representative of the burden of lung involvement was selected. (D–F) report the corresponding three-dimensional volume rendering images (IntelliSpace Portal v.8.0, Philips Medical Systems, Eindhoven, The Netherlands). The red volume represents the well-aerated parenchyma.