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. 2021 Oct 28;8:766486. doi: 10.3389/fmed.2021.766486

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Copyright © 2021 Bussolari, Palumbo, Fominsky, Nardelli, De Lorenzo, Vitali, De Cobelli, Rovere-Querini and Scandroglio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ratio of partial pressure arterial oxygen to fractional inspired oxygen (PaO₂/FiO₂₎ and C reactive protein (CRP) levels over time in three patients (A–C). Despite daily variations in minimum and maximum PaO₂/FiO₂ values, the trend shows progressive respiratory function improvements since the start of nintedanib in all patients.