Table 1.
Comparisons of baseline clinical profiles and CTP data between thrombectomy and medical management groups before and after PSM.
| Characteristic | Before PSM | After PSM | |||||
|---|---|---|---|---|---|---|---|
| MT group (n = 43) | MT group (n = 62) | p-value | MT group (n = 43) | MM group (n = 43) | p-value | ||
| Baseline demographic and clinical data | |||||||
| Age, years, mean ± SD | 66.51 ± 9.26 | 67.02 ± 13.18 | 0.829 | 66.51 ± 9.26 | 66.86 ± 12.65 | 0.884 | |
| Sex, male, n (%) | 27 (62.8) | 41 (66.1) | 0.725 | 27 (62.8) | 27 (62.8) | 1.000 | |
| Medical history, n (%) | |||||||
| Hypertension | 27 (62.8) | 45 (72.6) | 0.288 | 27 (62.8) | 29 (67.4) | 0.651 | |
| Diabetes mellitus | 8 (18.6) | 14 (22.6) | 0.623 | 8 (18.6) | 10 (23.3) | 0.596 | |
| Dyslipidemia | 6 (14.0) | 10 (16.1) | 0.760 | 6 (14.0) | 6 (14.0) | 1.000 | |
| Ischemic stroke | 7 (16.3) | 8 (12.9) | 0.627 | 7 (16.3) | 7 (16.3) | 1.000 | |
| Cardioembolic source | 16 (37.2) | 20 (32.3) | 0.599 | 16 (37.2) | 15 (34.9) | 0.822 | |
| Smoking | 15 (34.9) | 23 (37.1) | 0.816 | 15 (34.9) | 14 (32.6) | 0.820 | |
| Taking antiplatelet prior to stroke | 8 (18.6) | 12 (19.4) | 0.923 | 8 (18.6) | 8 (18.6) | 1.000 | |
| Taking anticoagulant prior to stroke | 3 (7.0) | 3 (4.8) | 0.687 | 3 (7.0) | 3 (7.0) | 1.000 | |
| Glucose at admission, mmol/L, median (IQR) | 6.7 (5.9, 7.9) | 6.95 (6.1, 8.9) | 0.444 | 6.7 (5.9, 7.9) | 6.6 (5.9, 8.9) | 0.782 | |
| Intravenous rtPA, n (%) | 19 (44.2) | 26 (41.9) | 0.819 | 19 (44.2) | 20 (46.5) | 0.829 | |
| DNT, min, median (IQR) | 34 (28, 45) | 34 (27, 48) | 0.827 | 34 (28, 45) | 32 (24.5, 46.5) | 0.844 | |
| NIHSS before evaluation of thrombectomy, median (IQR) | 5 (4, 5) | 5 (3, 5) | 0.138 | 5 (4, 5) | 5 (4, 5) | 0.835 | |
| Onset to door time, min, median (IQR) | 121 (60, 309) | 143 (60, 303) | 0.604 | 121 (60, 309) | 115 (59, 285) | 0.900 | |
| Onset to CTP time, min, median (IQR) | 219 (130, 415) | 235 (151, 381) | 0.555 | 219 (130, 415) | 236 (148, 358) | 0.832 | |
| Onset to puncture time, min, median (IQR) | 360 (275, 543) | NA | NA | 360 (275, 543) | NA | NA | |
| Onset to clot first reperfusion time, min, median (IQR) | 433 (345, 598) | NA | NA | 433 (345, 598) | NA | NA | |
| Local anesthesia, n (%) | 20 (46.5) | NA | NA | 20 (46.5) | NA | NA | |
| Successful recanalization (TICI 2b/3), n (%) | 42 (97.7) | NA | NA | 42 (97.7) | NA | NA | |
| Occlusion site | MCA M1, n (%) | 20 (46.5) | 24 (38.7) | 0.004 | 20 (46.5) | 18 (41.9) | 0.001 |
| MCA M2, n (%) | 3 (7.0) | 16 (25.8) | 3 (7.0) | 10 (23.3) | |||
| Proximal ICA, n (%) | 5 (11.6) | 4 (6.5) | 5 (11.6) | 3 (7.0) | |||
| Terminal ICA or tandem occlusion, n (%) | 11 (25.6) | 4 (6.5) | 11 (25.6) | 2 (4.7) | |||
| BA or PCA P1, n (%) | 4 (9.3) | 14 (22.6) | 4 (9.3) | 10 (23.3) | |||
| Baseline perfusion imaging data | |||||||
| Infarct core, ml, median (IQR) | 6 (3, 25) | 6.5 (3, 18) | 0.747 | 6 (3, 25) | 7 (3, 18) | 0.694 | |
| Penumbra, ml, median (IQR) | 89 (32, 118) | 63 (23, 103) | 0.062 | 89 (32, 118) | 73 (24, 103) | 0.240 | |
| DT > 3 s, ml, median (IQR) | 95 (37, 148) | 75.5 (27, 123.3) | 0.121 | 95 (37, 148) | 95 (29, 125) | 0.344 | |
| DT > 6 s, ml, median (IQR) | 19.0 (4.6, 36.8) | 11.5 (3.9, 31.9) | 0.265 | 19.0 (4.6, 36.8) | 11 (5, 35) | 0.426 | |
| Mismatch ratio, median (IQR) | 10.5 (4.6, 18.5) | 7.8 (3.0, 16.9) | 0.171 | 10.5 (4.6, 18.5) | 8.7 (3.5, 18.6) | 0.392 | |
| DT6/DT3 ratio, median (IQR) | 0.22 (0.11, 0.33) | 0.18 (0.08, 0.30) | 0.542 | 0.22 (0.11, 0.33) | 0.18 (0.05, 0.30) | 0.402 | |
Data are n (%), mean (SD), or median (IQR). p-values are based on chi-square, T-test, or Wilcoxon signed-rank test. PSM, propensity score matching; MT, mechanical thrombectomy; MM, medical management; rtPA, recombinant tissue plasminogen activator; DNT, door to needle time; NA, not applicable; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; DT, delay time; ICA, internal carotid artery; MCA, middle cerebral artery; PCA, posterior cerebral artery; BA, basilar artery.