TABLE 3.

Anatomic mapping of T1r2-expressing brain area.

Region	T1r2	Neuron	Glia	Vessel
Telencephalon
Olfactory bulb
Glomerular layer	++	O
External Plexiform and Mitral cell layer	++	O
Internal Plexiform and Granule cell layer	+++	O
Olfactory tubercle	++	O		O
Nucleus accumbens
Shell	+	O
Core	++	O
Claustrum	+	O
Lateral Septum
Intermediate	+	O
Dorsal	+	O
Ventral	++	O
Subfornical organ	++++		O
Cortex		O
Isocortex
Somatomotor areas	+	O		O
Somatosensory areas	+	O		O
Gustatory areas	+	O		O
Visceral areas	+	O		O
Auditory areas	+	O		O
Visual areas	+	O		O
Anterior cingulate areas	+	O		O
Prelimbic area	+			O
Infralimbic area	+			O
Orbital area	+			O
Agranular insular area	+			O
Retrosplenial area	+	O		O
Posterior parietal association areas	+	O		O
Temporal association areas	+	O		O
Perirhinal area	+	O		O
Ectorhinal area	+	O		O
Olfactory areas
Anterior olfactory nucleus	++	O
Tenia tecta	+	O		O
Piriform area	+			O
Nucleus of the lateral olfactory tract	+	O		O
Cortical amygdala nucleus	+	O		O
Piriform-amygdala area	+			O
Postpiriform transition area	+	O		O
Bed nucleus of the stria terminalis	+++	O
Preoptic area	+	O
Hippocampus
CA3
Rostral	+	O
Caudal	+	O
CA2	+	O
CA1 (Caudal)	+	O
Dentate gyrus	++	O
Fasciola cinerea	+	O
Indusium griseum	+	O
Amygdala
Central Amygdala	+++	O
Medial Amygdala	+	O
Basolateral Amygdala	–	X
Basomedial Amygdala	+	O
Lateral Amygdala	–	X
Organum vasculosum of the lamina terminalis	++	O
Diencephalon
Thalamus
Anterior thalamic nuclei	+++			O
Ventral posteromedial thalamic nuclei	+			O
Paraventricular nucleus	+			O
Lateral dorsal nucleus	++			O
Geniculate nucleus
Dorsolateral	+	O
Pregeniculate	+	O
Medial	+	O
Nucleus reuniens	+	O
Ventral anterior thalamic nucleus	++			O
Parafascicular thalamic nucleus	+			O
Subcommissural organ	++		O
Precommissural nucleus	+		O
Ventromedial thalamic nucleus	+			O
Medial habenular nucleus	++	O
Lateral habenular nucleus	+	O
Thalamic reticular formation	+			O
Hypothalamus
Anterior hypothalamus	–	X
Dorsomedial hypothalamus	++	O
Ventromedial hypothalamus	–	X
Paraventricular nucleus	++	O
Arcuate nucleus	++++	O
Lateral hypothalamus	+	O
Posterior hypothalamus	+	O
Suprachiasmatic nucleus	++++	O
Retrochiasmatic nucleus	–	X
Zona incerta	+	O
Ventromedial hypothalamus	–	X
Mesencephalon
Periaqueductal gray	+	O
Dorsal nucleus raphe	+	O
Interpenduncular nucleus	+++	O
Median raphe nucleus	+++	O
Premamillary nucleus	+	O
Mammillary nucleus	+	O
Pretectal nucleus	+	O
Superior colliculus	+	O
Inferior colliculus	+	O
Dorsal tegmental nucleus	+++	O
Ventral tegmental area	+	O
Parabrachial nucleus	+	O
Brainstem
Area postrema	++++	X	O
Nucleus tractus solitarius	+	O
Pontine central gray	++	O
Dorsal motor nucleus of the vagus nerve	+	O
Nucleus of the lateral lemniscus	+	O
Hypoglossal nucleus	+	O
Nucleus of Roller	–	X
Reticular formation	+	O
Medullary reticular nucleus	+	O
Intermediate reticular nucleus	+	O
Spinal nucleus of the trigeminal	+	O		O
Cerebellum
Molecular layer	+	O
Purkinje layer	+++	O
Granule cell layer	++	O