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. 2021 Oct 14;16(11):2752–2767. doi: 10.1016/j.stemcr.2021.09.009

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Transcriptome analysis of WWS and LGMDR9 myotubes

(A) Graph shows enriched biological functions in differentially expressed genes in WWS FP4 compared with WWS corrected (triangle symbol) and LGMDR9 (CDI73 and D01) compared with WT (diamond symbol) myotubes as revealed by IPA analysis. Dotted line represents the significance threshold. Data are plotted as –log (p value). Transcriptome analysis for each cell line was performed in triplicate.

(B) Graph shows enriched biological pathways in differentially expressed genes in WWS and LGMDR9 myotubes compared with respective control counterparts. Dotted line represents significance threshold. Data are plotted as –log (p value).

(C) Graph shows biological pathways enriched in 7 LGMDR9 patients muscle biopsies compared with WT controls in common with FKRP KO or FKRP patient-specific mutant myotubes. Data are plotted as –log (p value).