Table 2.

Estimated covariate effects (95% CIs) based on the model that included a linear term for age with random intercept, random slope and exponential correlation function and the model that included age using a spline with five knots, random intercept and exponential correlation function

	US		UK
	Linear function	Spline	Linear function	Spline
Sex=male	1.42 (0.70, 2.14)	1.80 (1.04, 2.55)	2.5 (1.33, 3.7)	2.71 (1.49, 3.93)
Age at diagnosis	0.59 (0.43, 0.74)	0.57 (0.42, 0.72)	0.62 (0.30, 0.95)	0.6 (0.28, 0.92)
Year of birth	0.37 (0.30, 0.43)	0.42 (0.35, 0.48)	0.24 (0.13, 0.35)	0.3 (0.19, 0.41)