Table 4.
Correlation analysis between follicular fluid redox markers and oocyte/embryo quality parameters
| FF redox marker | Oocyte/embryo quality parameter | Coefficient of correlation | P |
|---|---|---|---|
| All study participants (n = 121) | |||
| Glutathione reductase activity | Rate of fertilization | 0.31 | 0.008 |
| PON1 arylesterase activity | Number of follicles retrieved | 0.267 | 0.025 |
| PON1 arylesterase activity | Number of MII oocytes | 0.218 | 0.043 |
| PON1 arylesterase activity | Number of oocytes fertilized | 0.289 | 0.014 |
| PCOS (n = 50) | |||
| PON1 arylesterase activity | Percent grade I embryos | 0.399 | 0.048 |
| PON1 arylesterase activity | Number of oocytes fertilized | 0.355 | 0.043 |
| Controls (n = 71) | |||
| Catalase activity | Number of fertilized oocytes | 0.343 | 0.035 |
| TBARS | Number of fertilized oocytes | 0.495 | 0.002 |
| TBARS | Percent grade I embryos | − 0.531 | 0.034 |
| PON1 arylesterase activity | Pregnancy outcome | 0.513 | 0.035 |
| Total thiols | Number of follicles retrieved | 0.36 | 0.031 |
| Total glutathione | Percent grade I embryos | 0.661 | 0.027 |
| Total glutathione | Pregnancy outcome | 0.592 | 0.033 |
| Non-IR (PCOS n = 15, controls n = 59) | |||
| PON1 arylesterase activity | Number of follicles retrieved | 0.3 | 0.040 |
| IR (PCOS n = 35, controls n = 12) | |||
| Glutathione reductase activity | Rate of fertilization | 0.319 | 0.045 |
| PON1 arylesterase activity | Number of oocytes retrieved | 0.302 | 0.041 |
| PON1 arylesterase activity | Number of oocytes fertilized | 0.377 | 0.015 |
| AOPP | Number of oocytes retrieved | − 0.39 | 0.011 |
| AOPP | Number of MII oocytes | − 0.363 | 0.018 |
| AOPP | Number of oocytes fertilized | − 0.339 | 0.037 |
| Lean (PCOS n = 18, controls n = 45) | |||
| Catalase activity | Rate of fertilization | 0.305 | 0.039 |
| Glutathione reductase activity | Percent grade I embryos | 0.467 | 0.025 |
| Glutathione reductase activity | Pregnancy outcome | 0.406 | 0.029 |
| Obese (PCOS n = 32, controls n = 26) | |||
| PON1 arylesterase activity | Number of follicles retrieved | 0.432 | 0.002 |
| PON1 arylesterase activity | Number of oocytes retrieved | 0.429 | 0.001 |
| PON1 arylesterase activity | Number of MII oocytes | 0.378 | 0.005 |
| PON1 arylesterase activity | Number of oocytes fertilized | 0.505 | < 0.001 |
| AOPP | Number of MII oocytes | − 0.317 | 0.03 |
| AOPP | Number of oocytes fertilized | − 0.328 | 0.039 |
| AOPP | Percent grade I embryos | − 0.477 | 0.012 |
List of significant correlations obtained between follicular fluid redox markers and oocyte/embryo quality parameters (spearman’s correlation analysis). TBARS thiobarbituric acid reactive substances, AOPP advanced oxidized protein products, IR insulin resistant, NIR non-insulin resistant. P < 0.05 considered significant.