Table 5.
The changes in pro-/antioxidant markers measured follicular fluid samples in women with PCOS in comparison with control subjects
| Pro-/antioxidant marker | Trends reported by us in women with PCOS as compared to controls | Trends reported in other studies in women with PCOS as compared to controls |
|---|---|---|
| Superoxide dismutase | Activity in FF ↓ | Seleem et al 2014 ↓, Masjedi et al, 2019 ↓, Sabatini et al 2000 ↓, Pekel et al 2015 ↑, Bausenwein et al 2009 ↑ (in obese women than in lean women in both control and PCOS groups) |
| Transcript in GCs ↓ | Avila et al 2016 ↓ | |
| Catalase | Activity in FF (unchanged) | Masjedi et al 2019 ↓, Bausenwein et al 2009 ↑ (in obese women than in lean women in both control and PCOS groups) |
| Transcript in GCs (unchanged) | - | |
| Total glutathione | FF levels (unchanged) | Nishihara et al 2018 ↓ |
| GSSG | FF levels ↑ | - |
| GSH | FF levels ↓ | |
| Transcript in GCs ↓ (GCL, rate limiting enzyme, catalyses first step) | ||
| GSH/GSSG | FF levels ↓ | |
| Glutathione Peroxidase | Activity in FF ↓ | Masjedi et al 2019 ↓, Bausenwein et al ↑ (in obese women than in lean women in control group, unchaged in PCOS group) |
| Transcript in GCs ↓ | Masjedi et al 2019 ↓, Huang et al 2014 ↓ | |
| Glutathione reductase | Activity in FF ↓ | Bausenwein et al ↑ (in obese women than in lean women in PCOS group) |
| Total thiols | FF levels ↓ | Artimani et al 2018 ↓, Tola et al 2018 (unchanged) |
| Total antioxidant capacity | FF levels ↓ |
Becatti et al 2018 ↓, Masjedi et al 2019 ↓, Pekel et al 2015 ↓, Nishihara et al 2018 ↓, Artimani et al 2018 ↓, Nasiri et al 2015 ↓, Yilmaz et al 2016 (unchanged), Appasamy et al 2008 (unchanged) |
| PON1 arylesterase | Activity in FF ↓ |
Bacchetti et al 2019 ↓ (in obese women than in lean women), Meijide et al 2017 ↓ (in smaller follicles than in larger ones), Dadachanji et al 2018 (serum activity) ↓ |
| TBARS | FF levels ↑ |
Pekel et al 2015 ↑, Artimani et al 2018 ↑, Nasiri et al 2015 ↑ |
↑ higher, ↓ lower, FF follicular fluid, GSSG oxidized glutathione, GSH reduced glutathione, PON1 paraoxonase1, TBARS thiobarbituric acid reactive substances, AOPP advanced oxidized protein products