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. 2021 Jul 13;38(10):2651–2661. doi: 10.1007/s10815-021-02271-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic overview of ESTHER-1 and ESTHER-2 trial designs. The flow of patients is provided for fresh and frozen cycles using day 5 blastocysts obtained after ovarian stimulation with follitropin delta and follitropin alfa. Frozen cycles (optional) were started within 1 year after start of stimulation of the last fresh cycle in either of the trials. ESTHER Evidence-based Stimulation Trial with Human rFSH in Europe and Rest of World.