Fig. 1.

Mitochondrial transfer techniques. Ooplasmic transfer involves the transfer of mitochondrial from donor oocyte into patient oocyte (a). Maternal spindle transfer involves the transfer of the patient’s meiotic spindle into the enucleated donor oocyte followed by fertilization (b). Pronuclear transfer involves the transfer of pronuclei from the patient zygote into the enucleated donor zygote (c). Autologous germline mitochondrial energy transfer (AUGMENT) involves the injection of autologous mitochondria into the patient oocyte at the time of ICSI. These mitochondria were isolated from egg precursor cells (EggPCs) present in ovarian cortical tissue