Table 2.
Correlation of genotype and allele frequency of PIK3CA rs9838117 locus and ERBB2 rs1058808 with the risk of EOC
| EOC (n=587) | Control (n=650) | HWE P | OR (95%CI) * | P | |
|---|---|---|---|---|---|
| rs9838117 | |||||
| GG | 419 (71.38%) | 525 (80.77%) | 0.37 | 1.00 (reference) | |
| GT | 121 (20.61%) | 116 (17.85%) | 1.31 (0.98–1.74) | 0.08 | |
| TT | 47 (8.01%) | 9 (1.38%) | 6.54 (3.17–13.51) | <0.01 | |
| GT+TT | 168 (28.62%) | 125 (19.23%) | 1.68 (1.29–2.19) | <0.01 | |
| GG+GT | 540 (91.99%) | 641 (98.62%) | 1.00 (reference) | ||
| TT | 47 (8.01%) | 9 (1.38%) | 6.20 (3.01–12.76) | <0.01 | |
| G | 959 (81.69%) | 1166 (89.69%) | 1.00 (reference) | ||
| T | 215 (18.31%) | 134 (10.31%) | 1.95 (1.55–2.46) | <0.01 | |
| rs1058808 | |||||
| CC | 262 (44.63%) | 241 (37.08%) | 0.15 | 1.00 (reference) | |
| CG | 298 (50.77%) | 295 (45.38%) | 0.93 (0.73–1.18) | 0.59 | |
| GG | 27 (4.60%) | 114 (17.54%) | 0.22 (0.14–0.34) | <0.01 | |
| CG+GG | 325 (55.37%) | 409 (62.92%) | 0.73 (0.58–0.92) | <0.01 | |
| CC+CG | 560 (95.40%) | 536 (82.46%) | 1.00 (reference) | ||
| GG | 27 (4.60%) | 114 (17.54%) | 0.23 (0.15–0.35) | <0.01 | |
| C | 822 (70.02%) | 777 (59.77%) | 1.00 (reference) | ||
| G | 352 (29.98%) | 523 (40.23%) | 0.64 (0.54–0.75) | <0.01 | |
HWE, Hardy-Weinberg equilibrium; OR, odds ratio; CI, confidence interval
*Adjust age, BMI, number live-born, smoking, drinking, ovarian cancer family history