Table 3.
Stratified analysis of correlation between genotypes frequency at PIK3CA rs9838117 site and the risk of EOC
| EOC (n=587) | Control (n=650) | OR (95%CI) * | P | |
|---|---|---|---|---|
| Age | ||||
| <60 | ||||
| GG | 228 (67.86%) | 313 (81.51%) | 1.00 (reference) | |
| GT+TT | 108 (32.14%) | 71 (18.49%) | 2.08 (1.48–2.95) | <0.01 |
| ≥60 | ||||
| GG | 191 (76.10%) | 212 (79.70%) | 1.00 (reference) | |
| GT+TT | 60 (23.90%) | 54 (20.30%) | 1.23 (0.81–1.87) | 0.38 |
| BMI (kg/m2) | ||||
| <24 | ||||
| GG | 113 (68.90%) | 167 (84.77%) | 1.00 (reference) | |
| GT+TT | 51 (31.10%) | 30 (15.23%) | 2.51 (1.51–4.19) | <0.01 |
| ≥24 | ||||
| GG | 306 (72.34%) | 358 (79.03%) | 1.00 (reference) | |
| GT+TT | 117 (27.66%) | 95 (20.97%) | 1.44 (1.06–1.97) | 0.03 |
| Number live-born | ||||
| 0–2 | ||||
| GG | 294 (71.53%) | 386 (81.26%) | 1.00 (reference) | |
| GT+TT | 117 (28.47%) | 89 (18.74%) | 1.73 (1.26–2.36) | <0.01 |
| ≥3 | ||||
| GG | 125 (71.02%) | 139 (79.43%) | 1.00 (reference) | |
| GT+TT | 51 (28.98%) | 36 (20.57%) | 1.58 (0.97–2.57) | 0.09 |
| Smoking | ||||
| Yes | ||||
| GG | 66 (66.00%) | 97 (85.09%) | 1.00 (reference) | |
| GT+TT | 34 (34.00%) | 17 (14.91%) | 2.94 (1.52–5.69) | <0.01 |
| No | ||||
| GG | 353 (73.08%) | 428 (79.85%) | 1.00 (reference) | |
| GT+TT | 130 (26.92%) | 108 (20.15%) | 1.46 (1.09–1.95) | 0.01 |
| Drinking | ||||
| Yes | ||||
| GG | 60 (62.50%) | 81 (82.65%) | 1.00 (reference) | |
| GT+TT | 36 (37.50%) | 17 (17.35%) | 2.86 (1.47–5.57) | <0.01 |
| No | ||||
| GG | 359 (73.12%) | 444 (80.43%) | 1.00 (reference) | |
| GT+TT | 132 (26.88%) | 108 (19.57%) | 1.51 (1.13–2.02) | <0.01 |
| Ovarian cancer family history | ||||
| Yes | ||||
| GG | 64 (68.09%) | 19 (86.36%) | 1.00 (reference) | |
| GT+TT | 30 (31.91%) | 3 (13.64%) | 2.97 (0.82–10.81) | 0.15 |
| No | ||||
| GG | 355 (72.01%) | 506 (80.57%) | 1.00 (reference) | |
| GT+TT | 138 (27.99%) | 122 (19.43%) | 1.61 (1.22–2.13) | <0.01 |
BMI, body mass index; OR, odds ratio; CI, confidence interval
*Adjust age, BMI, number live-born, smoking, drinking, ovarian cancer family history