Table 4.

Stratified analysis of correlation between genotypes frequency at ERBB2 rs1058808 site and the risk of EOC

	EOC (n=587)	Control (n=650)	OR (95%CI) *	P
Age
<60
CC	156 (46.43%)	144 (37.50%)	1.00 (reference)
CG+GG	180 (53.37%)	240 (62.50%)	0.69 (0.51–0.93)	0.02
≥60
CC	106 (42.23%)	97 (36.47%)	1.00 (reference)
CG+GG	145 (57.77%)	169 (63.53%)	0.79 (0.55–1.12)	0.21
BMI (kg/m2)
<24
CC	77 (46.95%)	69 (35.03%)	1.00 (reference)
CG+GG	87 (53.05%)	128 (64.97%)	0.61 (0.40–0.93)	0.03
≥24
CC	185 (43.74%)	172 (37.97%)	1.00 (reference)
CG+GG	238 (56.26%)	281 (62.03%)	0.79 (0.60–1.03)	0.10
Number live-born
0–2
CC	189 (45.99%)	180 (37.89%)	1.00 (reference)
CG+GG	222 (54.01%)	295 (62.11%)	0.72 (0.55–0.94)	0.02
≥3
CC	73 (41.48%)	61 (34.86%)	1.00 (reference)
CG+GG	103 (58.52%)	114 (65.14%)	0.76 (0.49–1.16)	0.24
Smoking
Yes
CC	28 (28.00%)	47 (41.23%)	1.00 (reference)
CG+GG	72 (72.00%)	67 (58.77%)	1.80 (1.02–3.20)	0.06
No
CC	234 (48.05%)	194 (36.19%)	1.00 (reference)
CG+GG	253 (51.95%)	342 (63.81%)	0.61 (0.48–0.79)	<0.01
Drinking
Yes
CC	44 (45.83%)	37 (37.76%)	1.00 (reference)
CG+GG	52 (54.17%)	61 (62.24%)	0.72 (0.40–1.27)	0.32
No
CC	218 (44.40%)	204 (36.96%)	1.00 (reference)
CG+GG	273 (55.60%)	348 (63.04%)	0.73 (0.57–0.94)	0.02
Ovarian cancer family history
Yes
CC	41 (43.62%)	9 (40.91%)	1.00 (reference)
CG+GG	53 (56.38%)	13 (59.09%)	0.90 (0.35–2.30)	0.82
No
CC	221 (44.83%)	232 (36.94%)	1.00 (reference)
CG+GG	272 (55.17%)	396 (63.06%)	0.72 (0.57–0.92)	<0.01

BMI, body mass index; OR, odds ratio; CI, confidence interval

*Adjust age, BMI, number live-born, smoking, drinking, ovarian cancer family history