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. 2021 Oct 28;8:731214. doi: 10.3389/fmed.2021.731214

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Copyright © 2021 Che, Su, Li, Liu, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between drug sensitivity and the angiogenesis clusters. The box plots of the estimated IC50 for 12 types of common chemotherapeutic agents are shown in (A–L) for cluster 1 (yellow), cluster 2 (blue), and cluster 3 (red). The 12 types of chemotherapeutic agents are pazopanib, sorafenib, sunitinib, nilotinib, vorinostat, axitinib, gefitinib, temsirolimus, lapatinib, metformin, bosutinib, and tipifarnib. The P-values are displayed above the clusters and the P < 0.05 were considered statistically significant. The box plots showed drug sensitivities among the angiogenesis clusters were different.