Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 28;8:731214. doi: 10.3389/fmed.2021.731214

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Che, Su, Li, Liu, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Construction of a risk model using the least absolute shrinkage and selection operator (LASSO)–Cox regression analysis. (A) The plot shows the result of co-expression relationships of 24 angiogenesis pathway genes in KIRC. In the color bar on the right side, blue represents positive correlation and yellow represents negative correlation. (B) The LASSO coefficient profiles of angiogenesis pathway genes in KIRC. (C) The distribution and median value of the risk scores. Fifteen genes were screened by LASSO Cox regression analysis. (D) The survival curve was obtained based on this model. The overall survival rates of patients in the high-risk group were significantly lower than those of the patients in the low-risk group. Blue represents the high-risk group and yellow represent the low-risk group. (E–H) ROC curve of 3-, 5-, 7-, and 10-years, area under the curve (AUC) of the curve are 0.734, 0.752, 0.763, and 0.787, respectively. (I) The correlation of risk score and the clinicopathological characteristics. The color bar shows the expression of genes. Yellow represents the upregulation of genes, blue represents the downregulation of genes (***p < 0.001).