Table 4.
Changes in study variables on the first day of assessment, according to response to CPP challenge and baseline tissue hypoxia.
| Step 1 | Step 2 | Step 3 | p-value | ||
|---|---|---|---|---|---|
| Responders(n = 25) | MAP, mmHg | 83 (80–89) | 95 (90–98) | 103 (100–108) | <0.01 |
| ICP, mmHg | 11 (9–17) | 11 (10–15) | 11 (9–15) | 0.26 | |
| CPP, mmHg | 72 (70–74) | 82 (80–85) | 91 (89–95) | <0.01 | |
| PbtO2, mmHg | 17 (16–19) | 21 (18–22) | 24 (22–26) | <0.01 | |
| No responders (n = 28) | MAP, mmHg | 83 (82–88) | 96 (92–99) | 107 (101–110) | <0.01 |
| ICP, mmHg | 12 (6–14) | 12,5 (9–15) | 12 (10–15) | 0.01 | |
| CPP, mmHg | 74 (72–76) | 84 (80–87) | 94 (90–97) | <0.01 | |
| PbtO2, mmHg | 22 (20–26) | 23 (22–26) | 24 (22–27) | <0.01 | |
| Normal PbtO2(n = 27) | MAP, mmHg | 83 (82–88) | 95 (92–100) | 105 (100–110) | <0.01 |
| ICP, mmHg | 12 (6–14) | 12 (9–14) | 11 (9–14) | 0.43 | |
| CPP, mmHg | 74 (71–76) | 85 (81–88) | 94 (91–97) | <0.01 | |
| PbtO2, mmHg | 23 (21–26) | 24 (23–28) | 26 (24–29) | <0.01 | |
| Tissue hypoxia(n = 26) | MAP, mmHg | 86 (82–89) | 95 (91–98) | 106 (100–110) | <0.01 |
| ICP, mmHg | 11 (9–17) | 11 (10–17) | 12 (9–18) | <0.01 | |
| CPP, mmHg | 72 (70–74) | 82 (79–85) | 91 (88–96) | <0.01 | |
| PbtO2, mmHg | 17 (16–18) | 20 (18–22) | 22 (21–24) | <0.01 |
MAP, mean arterial pressure; ICP, intracranial pressure; CPP, cerebral perfusion pressure; PbtO2, Brain tissue oxygenation.