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. 2021 Oct 28;12:762016. doi: 10.3389/fimmu.2021.762016

Figure 1.

Figure 1

Gal-9 attenuates MSU crystals-induced gouty inflammation in mouse knee joints. Mice were treated with intra-articular (i.a.) dose of Gal-9 (9μg/20μl) or vehicle (PBS, 20μl) 30 mins after i.a. stimulation with MSU crystals (200μg/20μl) in the right knee joints. (A) Joint inflammation score (0-3 in increments of 0.25) and (B) joint inflammation oedema was evaluated at 4, 18, 24 and 48h after the stimulus with MSU. Data (expressed as joint inflammation score and Δ increase of knee joints mm respectively) are presented as means ± SEM of n = 6 mice per group. Statistical analysis was conducted by one- or two-way ANOVA followed by Bonferroni’s for multiple comparisons. ##P ≤ 0.01, ####P ≤ 0.0001 vs Ctrl group; **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 vs MSU group.