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. 2021 Oct 28;9:757378. doi: 10.3389/fbioe.2021.757378

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Copyright © 2021 Wang, Wang, Li, Song, Xia, Wang, Zhang, Wu and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unsupervised hierarchical clustering and PCA of stromal regions based on mRNA expression and all ROI clustering. (A) Unsupervised hierarchical clustering of mRNA expression in the stroma ROIs of chemotherapy or combinational therapy patients. ROIs are grouped based on treatment options and patient IDs. (B,C) PCA plots of mRNA expression in the stroma ROIs grouped by patients (B) or therapies (C), respectively. (D,E) PCA plots of mRNA expression in all ROIs (tumor and stroma) grouped by patients (D) or therapies (E), respectively.