. 2021 Oct 28;12:773983. doi: 10.3389/fimmu.2021.773983

Table 2.

Correlation between clinical outcomes and CD4⁺ and CD8⁺ T-cell phenotypes.

T-cell phenotypes	Clinical outcome	R values	p-Values
CD4⁺IL-2⁺ total frequencies	Monocytes	0.271	0.0212
CD4⁺TNF-α⁺ total frequencies	Hemoglobin	0.336	0.0041
	Hematocrit	0.276	0.0198
CD4⁺IFN-γ⁺ total frequencies	Monocytes	0.383	0.0009
CD4⁺IFN-γ⁺ iMFI	Monocytes	0.352	0.0024
CD4⁺IL-2⁺TNF-α⁻IFN-γ⁻	Monocytes	0.293	0.0142
CD4⁺IL-2⁻TNF-α⁺IFN-γ⁻	Monocytes	0.273	0.0228
CD4⁺IL-2⁻TNF-α⁻IFN-γ⁺	Monocytes	0.264	0.0279
CD4⁺IL-2⁺TNF-α⁻IFN-γ⁺	Monocytes	0.283	0.0168
CD4⁺IL-2⁺TNF-α⁺IFN-γ⁺	Monocytes	0.331	0.0048
CD8⁺IL-2⁻TNF-α⁺IFN-γ⁻	Spleen size	−0.306	0.0093
	Hemoglobin	0.262	0.0267
	Neutrophils	0.287	0.0154
CD8⁺IL-2⁺TNF-α⁺IFN-γ⁺	Hemoglobin	0.334	0.0041
	Hematocrit	0.249	0.0357
CD8^High	Spleen size	−0.325	0.0053
	Hemoglobin	0.308	0.0084
	Hematocrit	0.270	0.0224
	Leukocytes	0.501	<0.0001
	Neutrophils	0.442	<0.0001
	Lymphocytes	0.262	0.0259
	Monocytes	0.348	0.0027
	Eosinophils	0.407	0.0015
CD8^Low	Leukocytes	−0.257	0.0291
CD8^Low	Monocytes	−0.368	0.0014
MA CD4⁺IFN-γ⁺ total frequencies	Liver size	−0.344	0.0499
MA CD4⁺IFN-γ⁺ total frequencies	Monocytes	0.432	0.0120
MA CD4⁺IFN-γ⁺ iMFI	Liver size	−0.348	0.0467
MA CD4⁺IFN-γ⁺ iMFI	Monocytes	0.381	0.0286
MA CD4⁺TNF-α⁺ total frequencies	Hemoglobin	0.364	0.0371
	Hematocrit	0.369	0.0245
	Platelets	0.387	0.0258
	Leukocytes	0.487	0.0040
	Neutrophils	0.458	0.0073
MA CD4⁺TNF-α⁺ iMFI	Liver size	−0.472	0.0055
	Spleen size	−0.566	0.0006
	Platelets	0.358	0.0404
	Leukocytes	0.418	0.0155
MA CD8⁺IFN-γ⁺ total frequencies	Platelets	−0.388	0.0496
LAMB CD4⁺IL-2⁺ total frequencies	Lymphocytes	−0.274	0.0427
LAMB CD4⁺IL-2⁺ iMFI	Eosinophils	0.316	0.0412
LAMB CD8⁺IL-2⁺ iMFI	Lymphocytes	−0.274	0.0450

Correlation analysis between variables was performed using Spearman’s two-tailed method.

LAMB, liposomal amphotericin B; MA, meglumine antimoniate; iMFI, integrated mean fluorescence intensity.