Table 2.
Univariate and multivariate analyses of respiratory failure in children with severe CAP.
| Factor | Without respiratory failure (n = 51) | Respiratory failure after enrollment (n = 71) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|
| z/χ2 value | P value | OR (95% CI) | P value | |||
| Age, months | 22.00 (10.00–53.00) | 10.00 (3.00–33.00) | 2.78 | 0.005 | 0.985 (0.973–0.998) | 0.018 |
| Male, n (%) | 35 (68.63) | 42 (59.15) | 1.14 | 0.285 | ||
| HBP, ng/mL | 62.07 (28.32–109.80) | 110.22 (62.24–192.54) | 3.32 | 0.001 | 1.008 (1.003–1.013) | 0.003 |
| CRP, mg/L | 8.91 (1.48–31.70) | 12.50 (2.11–44.70) | 1.06 | 0.291 | ||
| IL-6, pg/mL | 17.27 (6.37–32.50) | 32.30 (12.30–95.60) | 3.16 | 0.002 | 0.999 (0.999–1.000) | 0.217 |
| PCT, ng/mL | 0.22 (0.10–0.56) | 0.30 (0.08–1.29) | 0.57 | 0.570 | ||
| WBC, 109/L | 9.79 (6.49–13.94) | 10.93 (7.26–15.96) | 1.33 | 0.185 | ||
| N% | 55.60 (35.00–73.00) | 63.60 (43.40–76.20) | 1.23 | 0.219 | ||
| D-dimer, μg/mL | 0.62 (0.42–1.03) | 0.87 (0.53–3.26) | 2.44 | 0.015 | 1.100 (0.952–1.271) | 0.198 |
Measurement data were presented as medians (interquartile ranges) and analyzed by the Mann–Whitney U test. Numerical data were presented as numbers and percentages (%) and analyzed by the chi-squared test. Statistically significant factors identified in the univariate analysis were further analyzed using a binary multivariate logistic regression analysis. CAP, community-acquired pneumonia; HBP, heparin-binding protein; CRP, C-reactive protein; IL-6, interleukin-6; PCT, procalcitonin; WBC, white blood cell count; N%, neutrophil percentage; OR, odds ratio; 95% CI, 95% confidence interval.