Table 1.

Comparison between different studies with measurements of the oxytocin (OXT) levels in different fluids (CSF, plasma, saliva and urine).

Author	n	Sex	Age	Detection technique	Fluid measured	Statistical analysis	Statistical report
Takagi et al. (1985)	36	F	19–45	RIA	CSF/Plasma	Correlation	NS
Takeda et al. (1985)	42	M F	±30 - ± 40	RIA	CSF/Plasma	Correlation	NS
Holt-Lunstad et al. (2008)	72	M F	20–39	EIA	Plasma/Saliva	Correlation	p < 0.01
Feldman et al. (2010)	112	M F	±30	ELISA	Plasma/Saliva	Spearman Correlation	p < 0.001
Grewen et al. (2010)	20	M		EIA	Plasma/Saliva	Pearson Correlation	Basal p = 0.022
Feldman et al. (2011)	112	M F	±30	ELISA	Plasma/Saliva/Urine	Pearson Correlation	pOXT & sOXT (p < 0.001) pOXT & uOXT (NS) sOXT & uOXT (NS)
Hoffman et al. (2012)	20	M	±30	EIA	Plasma/Saliva/Urine	Pearson Correlation	pOXT & sOXT (NS) pOXT & uOXT (NS)
Jokinen et al. (2012)	47	M F	23–66	RIA	CSF/Plasma	Spearman Correlation	NS
Kagerbauer et al. (2013)	41	M F	19–81	RIA	CSF/Plasma	Spearman Correlation	NS
Striepens et al. (2013)	15	M	19–64	RIA	CSF/Plasma	Spearman Correlation	NS
Wang et al. (2013)	215	M F	20–62	RIA	CSF/Plasma	Linear regression	p < 0.001
Carson et al. (2015)	27	M F	4–64	EIA	CSF/Plasma	Linear regression	p = 0.0064
Javor et al. (2014)	30	M	18–40	ELISA	Plasma/Saliva	Correlation/linear regression	NS
Martin et al. (2014)	41	M F	19–58	RIA	CSF/Plasma	Spearman Correlation	NS
Behr et al. (2017)	38	M	18–45	ELISA	Serum/Saliva	Spearman Correlation	NS
Martin et al. (2018)	50	M F	20–86 (±65)	RIA	Plasma/Saliva/CSF	Spearman Correlation	sOXT & cOXT (p < 0.001) pOXT & cOXT (p = 0.003) sOXT & pOXT (p = 0.10)

Notes: F female, M male, CSF cerebrospinal fluid, NS non-significant, pOXT plasmatic oxytocin, sOXT salivary oxytocin, uOXT urine oxytocin, cOXT central oxytocin.