Table 13.

Meta-Analysis of Comparison 8: Later (Delayed) Cord Clamping at ≥30 Seconds Compared With Physiological Approach to Cord Clamping (Until Cessation of Pulsation of the Cord or Based on Vital Signs Monitoring/Initiation of Breathing) for Term and Late Preterm Infants

Outcome	Included studies	Total, n	Certainty of evidence	RR (95% CI); I2	Absolute difference (95% CI) or mean difference (95% CI); I2
Neonatal mortality	Sun et al,287 2017	338	Very low	5.00 (0.24 to 103.37)	12/1000 more infants (10 fewer–30 more per 1000) died when later (delayed) cord clamping was intended compared with when a physiological approach was intended
Hct within 24 h after birth	Chen et al,259 2018	540	Very low		MD, –1.40% (–2.79 to –0.01); not available*
Hb concentration within 7 d after birth	Sun et al,287 2017	338	Very low		MD, –1.70 g/dL (–1.97 to –1.43); not available*
Hct within 7 d after birth	Sun et al,287 2017	338	Very low		MD, –6.5% (–7.64 to –5.16); not available*
Severe PPH (≥1000 mL)	Chen et al,259 2018	540	Very low	1.82 (0.10 to 33.4); not available*	9/1000 more mothers (10 fewer–30 more per 1000) had a PPH (≥1000 mL) when later cord clamping was intended than when a physiological approach was intended

Hb indicates hemoglobin; Hct, hematocrit; MD, mean difference; PPH, postpartum hemorrhage; and RR, risk ratio.

^*Only 1 study available.