Table 5.
Drug combinations in registered RCTs
| Drug Combinations in registered/published RCTs | Number of trials N |
|---|---|
| Antimalaria + Antibiotic with/without following combinations | 50 |
| HCQ + azithromycin | 37 |
| HCQ + azithromycin + doxycycline | 1 |
| artesunate-atovaquone + azithromycin | 1 |
| artesunate-amodiaquine + azithromycin | 2 |
| HCQ + azithromycin + zinc | 2 |
| HCQ + azithromycin + zinc + vitamin C + vitamin D3 | 1 |
| HCQ + azithromycin + LPV/r | 1 |
| HCQ + azithromycin + tocilizumab | 2 |
| HCQ + azithromycin + oseltamivir | 2 |
| mefloquine + azithromycin + tocilizumab | 1 |
| Antiviral combinations | 11 |
| ASC09 + ritonavir | 2 |
| ASC09 + ritonavir + oseltamivir | 1 |
| LPV/r + favipiravir | 2 |
| LPV/r + oseltamivir | 1 |
| LPV/r + ribavirin | 1 |
| sofosbuvir + ledipsavir | 1 |
| oseltamivir + ritonavir | 1 |
| oseltamivir + darunavir + ritonavir | 1 |
| favipiravir + maraviroc | 1 |
| Antimalaria + Antiviral | 23 |
| HCQ + LPV/r | 11 |
| HCQ + favipiravir | 4 |
| HCQ + sofosbuvir + daclatasvir | 2 |
| HCQ + remdesivir | 1 |
| HCQ + ribavirin | 1 |
| CQ + darunavir-ritonavir + favipiravir | 1 |
| oseltamivir + CQ | 2 |
| oseltamivir + HCQ | 1 |
| tenofovir + LPV/r + CQ | 1 |
| Antiviral + Immunomodulator with/without following combinations | 13 |
| IFN + remdesivir | 1 |
| IFN + LPV/r | 3 |
| IFN + LPV/r + ribavirin | 1 |
| IFN + ribavirin | 1 |
| IFN + danoprevir + ritonavir | 1 |
| IFN + umifenovir | 1 |
| IFN + ASC09 + ritonavir | 1 |
| tocilizumab + favipiravir | 1 |
| IFN + HCQ + LPV/r | 3 |
| tocilizumab + remdesivir | 1 |
| Antiparasitic with/without following combinations | 17 |
| ivermectin + doxycycline | 4 |
| ivermectin + HCQ | 1 |
| ivermectin + losartan | 1 |
| ivermectin + nitazoxide | 2 |
| nitazoxanide + ribavirin | 1 |
| nitazoxanide + ribavirin + ivermectin | 1 |
| nitazoxanide + favipiravir | 1 |
| nitazoxanide + HCQ | 1 |
| levamisole + inosine pranobex | 1 |
| levamisole + formoterol + budesonide | 2 |
| niclosamide + camostat mesylate | 1 |
| nitazoxanide + HCQ + ribavirin | 1 |
| Immunomodulator with/without following combinations | 8 |
| tacrolimus + methylprednisolone | 1 |
| tocilizumab + pembrolizumab | 1 |
| tocilizumab + ruxolitinib | 1 |
| IFN + dexamethasone + IVIG | 1 |
| IFN + HCQ | 1 |
| IFN + bromhexine + umifenovir | 1 |
| IFN-kappa + TFF2 | 1 |
| ruxolitinib + anakinra | 1 |
| Other combinations | 48 |
Abbreviations: HCQ hydroxychloroquine, CQ chloroquine, IFN interferon, LPV/r lopinavir-ritonavir, IVIG intravenous immunoglobulin, TTF2 trefoil factor 2