Table 1.
The potential role of TDP-43 in cancers.
| Tumor | Dysregulation | Associated factor | Downstream | Mechanism | Biological function | Function | Ref./PMID |
|---|---|---|---|---|---|---|---|
| Breast cancer | – | Curcumin | - | - | Promoted cell apoptosis | Tumor suppressor | 21239154 |
| Breast cancer | – | – | – | TDP-43 35 kDa fragment | Promoted cell apoptosis | Tumor suppressor | 29421661 |
| Breast cancer | Downregulated | TRIM16 | CDK6, E2F1, pRb | mRNA stability | Inhibited cell cycle | Tumor suppressor | 26902425 |
| Triple-negative breast cancer | Upregulated | SRSF3 | PAR3, NUMB | mRNA splicing | Promoted proliferation and metastasis | Oncogenic factor | 29581274 |
| Lung cancer | – | miR-423-3p | CRK, LCP2, ITGA9 | miRNA interaction | Promoted cell migration | Oncogenic factor | 28952053 |
| – | miR-500a-3p | LIF, PAPPA | miRNA processing and interaction | Inhibited tumors | Tumor suppressor | 28952053 | |
| Non-small cell lung cancer, NSCLC | Upregulated | MALAT1 | ABCA1, LPHN2 | lncRNA stability | Promoted cell proliferation and migration | Oncogenic factor | 26265046 |
| Lung cancer | Downregulated | FasL | – | mRNA stability | Promoted cell apoptosis | Tumor suppressor | 31978067 |
| Glioblastoma | Upregulated | HDAC6 | – | mRNA stability | Activated autophagy, suppressed stress-induced apoptosis | Oncogenic factor | 28915616 |
| Neuroblastoma | Downregulated | TRIM16 | CDK6, E2F1, pRb | mRNA stability | Inhibited cell cycle | Tumor suppressor | 26902425 |
| Neuroblastoma | – | – | – | – | – | Good prognosis indicator | 30394813 |
| Neuroblastoma | – | β-N-methylamino-L-alanine | – | TDP-43 truncated forms (C-terminal fragments), phosphorylated and high molecular weight forms of TDP-43 | – | – | 23665941 |
| Hepatocellular carcinoma | Upregulated | miR-520 family | PFKP | Transcription inhibition | Promoted glycolysis and proliferation | Oncogenic factor | 23389994 |
| Hepatocellular carcinoma | Upregulated | GSK3β | Wnt/β-catenin signaling pathway | mRNA translation | Promoted proliferation and metastasis | Oncogenic factor | 33163270 |
| Melanoma | Upregulated | – | GLUT4 | – | Promoted proliferation and metastasis | Oncogenic factor | 27786596 |
| Cervical cancer (Hela cell) | – | p53 | – | – | Induced p53-dependent G2/M arrest and p53-independent cell death | Tumor suppressor | 22133803 |
| Cervical cancer (Hela cell) | – | – | – | DNA damage | Prevented R loops accumulation and DNA damage | – | 33301444 |
| Ewing sarcoma | – | – | – | Mutation rs9430161 | Higher tumor susceptibility | – | 22327514 |
| Leukemic (pre-B-ALL cell line MHH-CALL3 cell) | Upregulated | – | – | – | – | – | 21783252 |
| Prostate cancer | Downregulated | – | – | – | – | Tumor biomarker | 31404106 |
| Colon cancer | – | 1,25(OH)2D3 | – | – | – | Tumor suppressor | 21864731 |