TABLE 2.
Comparison of behavioural function test among the four groups in subchronic general toxicity study
| Parameters | 0 cells/head | 1 × 104 cells/head | 3 × 104 cells/head | 1 × 105 cells/head |
|---|---|---|---|---|
| Sex: Male | ||||
| Negative geotaxis | 10.10 ± 0.32 | 10.20 ± 0.42 | 10.00 ± 0.00 | 10.00 ± 0.00 |
| Traction test | 15.30 ± 0.48 | 15.80 ± 1.03 | 15.70 ± 0.95 | 16.00 ± 0.94 |
| Pupillary reflex | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 |
| Acoustic startle response | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 |
| Rotating rod test | 23.50 ± 0.71 | 23.60 ± 0.84 | 23.30 ± 0.67 | 23.60 ± 0.70 |
| Sex: Female | ||||
| Negative geotaxis | 10.10 ± 0.32 | 10.00 ± 0.00 | 10.00 ± 0.00 | 10.20 ± 0.42 |
| Traction test | 16.30 ± 1.64 | 15.80 ± 1.32 | 16.00 ± 1.33 | 15.70 ± 0.82 |
| Pupillary reflex | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 |
| Acoustic startle response | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 | 22.00 ± 0.00 |
| Rotating rod test | 23.30 ± 0.48 | 23.20 ± 0.42 | 23.60 ± 0.70 | 24.10 ± 0.74 |
Values are post‐natal day (PND) mean ± standard error of 10 rats/sex/group. The evaluation of negative geotaxis, traction test, acoustic startle response, pupillary reflex and rotating rod test began on PND 10, PND 15, PND 22 and PND 22, respectively.