TABLE 3.
Comparison of lymphocyte phenotyping analysis among the four groups in subchronic general toxicity study
| Cell population (Phenotype) | 0 cells/head | 1 × 104 cells/head | 3 × 104 cells/head | 1 × 105 cells/head |
|---|---|---|---|---|
| Sex: Male | ||||
| Total T cells (CD3+) | 52.26 ± 4.85 | 51.14 ± 6.46 | 49.18 ± 3.87 | 52.47 ± 2.24 |
| Th cells (CD3+ CD4+) | 37.51 ± 4.45 | 34.72 ± 5.83 | 34.41 ± 3.41 | 36.23 ± 2.37 |
| Tc cells (CD3+ CD8+) | 14.71 ± 1.09 | 16.94 ± 1.22 a | 14.91 ± 0.86 | 16.35 ± 1.36 |
| Ratio (CD4:CD8) | 2.56 | 2.05 | 2.31 | 2.23 |
| B cells (CD3− CD45RA+) | 45.18 ± 4.67 | 42.96 ± 5.38 | 46.87 ± 3.53 | 44.70 ± 2.91 |
| NK cells (CD3‐ CD161a+) | 0.97 ± 0.22 | 0.95 ± 0.30 | 0.82 ± 0.23 | 0.89 ± 0.22 |
| Sex: Female | ||||
| Total T cells (CD3+) | 55.13 ± 8.24 | 55.25 ± 8.17 | 54.28 ± 5.51 | 55.62 ± 4.86 |
| Th cells (CD3+ CD4+) | 39.87 ± 4.71 | 40.05 ± 5.48 | 39.18 ± 4.62 | 38.45 ± 3.91 |
| Tc cells (CD3+ CD8+) | 15.48 ± 4.09 | 15.43 ± 3.89 | 15.24 ± 3.42 | 17.29 ± 2.23 |
| Ratio (CD4:CD8) | 2.71 | 2.71 | 2.73 | 2.25 |
| B cells (CD3− CD45RA+) | 41.63 ± 7.45 | 41.19 ± 7.13 | 42.83 ± 4.90 | 40.83 ± 5.28 |
| NK cells (CD3− CD161a+) | 1.12 ± 0.28 | 1.09 ± 0.33 | 1.42 ± 0.69 | 1.02 ± 0.15 |
Values are percentage mean ± standard error of 5 rats/sex/group. The lymphocyte phenotyping analysis was conducted on PND 57.
Tc cells, cytotoxic T cells; Th cells, helper T cells.
a
Dunnett's test significant at the 0.05 level.