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. 2021 Oct 15;54:101357. doi: 10.1016/j.molmet.2021.101357

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Dpp4+ progenitors contribute extensively to adipogenesis in retroperitoneal WAT. (A) Gross histology showing the anatomic location of the mouse retroperitoneal WAT. Murine retroperitoneal WAT is contained within a sheath of reticular interstitial connective tissue that affixes the depot within the retroperitoneal space against the psoas muscles. (B) IHC staining of retroperitoneal WAT from Dpp4^CreER; mGFP mice at the pulse timepoint [mGFP: lineage traced cells (green), DPP4: cells currently expressing DPP4 (magenta), PLIN1: mature adipocytes (red), DAPI: nuclei (blue); scale bar = 380 μM]. Individual antibody staining is represented in grayscale on the right-side inset panels (inset scale bar = 100 μM). (C) H&E and IHC staining of Dpp4^CreER retroperitoneal adipose under chow (left panels) or high fat diet (right panels) feeding conditions.