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. 2021 Oct 28;12:778359. doi: 10.3389/fimmu.2021.778359

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Copyright © 2021 Ma, Sun, Li, Deng, Zhang, Yang, Han, Huang, Fang, Liao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blockade of IL-6/IL-6R signaling attenuates acute antibody-mediated rejection. (A) Survival rate in the control, tocilizumab, and IL-6^-/- groups (n = 5/group). (B, C) Changes in donor-specific antibody IgG and IgM before and after transplantation in each group (n = 4/group). (D, E) Representative hematoxylin and eosin staining and C4d immunohistochemistry staining of cardiac allografts obtained 4 d post-operation in each group (n = 4/group). *P<0.05; **P<0.01; ***P<0.001; ST, skin transplantation; CT, cardiac transplantation. NS, no significance.