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Blockade of IL-6/IL-6R signaling reduces B cells. B cells (CD19+) were detected by flow cytometry 4 d after cardiac transplantation in the control, tocilizumab, and IL-6-/- groups. Representative dot plots for frequencies and quantitative analysis of frequencies and counts of B cells in circulation (A–C), spleens (D–F), and cardiac allografts (G–I) (n = 4/group). *P<0.05; **P<0.01; ***P<0.001; NS, no significance.
