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. 2021 Oct 28;12:778359. doi: 10.3389/fimmu.2021.778359

Figure 5.

Figure 5

Blockade of IL-6/IL-6R signaling reduces macrophages and T cells infiltration in allografts detected by flow cytometry. Macrophages (CD11b+F4/80+), T cells (CD3+), CD4+ T cells (CD3+CD4+), and CD8+ T cells (CD3+CD8+) were detected in allografts 4 d after transplantation in the control, tocilizumab, and IL-6-/- groups. Representative dot plots for frequencies and quantitative analysis of frequencies and counts of macrophages (A–C), T cells (D–F), CD4+ T cells and CD8+ T cells (G–K) (n = 4/group). *P<0.05; **P<0.01; ***P<0.001; NS, no significance.