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. 2021 Oct 28;12:778359. doi: 10.3389/fimmu.2021.778359

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Copyright © 2021 Ma, Sun, Li, Deng, Zhang, Yang, Han, Huang, Fang, Liao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blockade of IL-6/IL-6R signaling reduces macrophages and T cells infiltration in allografts detected by immunohistochemistry staining. Representative images and quantitative analysis of CD68 (A), CD3 (B), CD4 (C), and CD8 (D) in the control, tocilizumab, and IL-6^-/- groups (n = 4/group). *P<0.05; **P<0.01; ***P<0.001; NS, no significance.