TABLE 1.
Neoplasms found in transgenic females carrying the MMTV-CDC37 transgene
| Pathology | Line | % Mice affected (no./total) |
|---|---|---|
| Mammary ductal adenosquamous carcinoma | MMTV-CDC37.1 | 60 (6/10) |
| MMTV-CDC37.2 | 20 (4/20) | |
| Lymphoma | MMTV-CDC37.1 | 50 (5/10) |
| MMTV-CDC37.2 | 20 (4/20) | |
| Mammary ductal adenocarcinoma | MMTV-CDC37.1 | 10 (1/10) |
| MMTV-CDC37.2 | 0 (0/20) | |
| Sarcoma | MMTV-CDC37.1 | 0 (0/10) |
| MMTV-CDC37.2 | 5 (1/20) | |
| Total affected | MMTV-CDC37.1a | 100 (10/10) |
| MMTV-CDC37.2b | 45 (9/20) | |
| Nontransgenicc | 0 (0/30) |
a
Tumors occurred between 18 and 22 months of age.
b
All animals were sacrificed and analyzed at 17 months of age without outward signs of transformation.
c
Animals were examined in parallel with MMTV-CDC37 mice at 17 to 22 months of age.