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Dendritic blebbing is attenuated by treatment with the channel blocker MK801. Representative images of rat cortical neurons transfected with pCI-neo empty vector, GluN2A-WT, and GluN2A-P552R and co-treated with 10 µM MK801 (A). GluN2A-P552R expressing neurons treated with 10 µM MK801 show a significant reduction in blebbing (B) (one-way ANOVA, p > 0.05, n = 9). Data are ± SEM from three independent experiments with three coverslips analyzed per experiment.
