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. 2021 Oct 17;11(20):9918–9936. doi: 10.7150/thno.66378

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Decreased melanin synthesis via downregulation of MITF by CRTC3 deficiency. (A) mRNA and (B) protein level of melanogenesis-related genes in control and CRTC3KD Mel-Ab cells at 0, 24, 48, and 72 h after FSK treatment. (C) EM images (left panel) and melanosome quantification (right panel) of control and CRTC3KD Mel-Ab cells at 0 and 72 h after FSK treatment (Ba r= 2 μm). (D) mRNA and (E) protein levels of melanogenesis-related genes in control and CRTC3KD Mel-Ab cells within 6 h after FSK treatment. (F) mRNA level of melanogenesis-related genes in primary cultured mouse melanocytes from CTRL mice within 6 h after FSK treatment. (G) mRNA and (H) protein levels of melanogenesis-related genes in Mel-Ab cells within 6 h after FSK or TPA treatment.