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CST6 recombinant protein effectively inhibits bone metastasis of breast cancer in mice. (A) Representative BLI, micro-CT, H&E and TRAP staining images of SCP2 bone metastases at week 5 after treatment of 1 mg/kg/day wild type or mutant CST6 proteins (n = 10 mice per group). Scale bar, 200 μm. (B, C) BLI (B) and osteoclast (C) quantitation of the metastasis. (D) Survival analysis of the mice. *P < 0.05, **P < 0.01; ns, not significant.
