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. 2021 Oct 28;15:747229. doi: 10.3389/fnins.2021.747229

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Copyright © 2021 de Melo Reis, Isaac, Freitas, de Almeida, Schuck, Ferreira, Andrade-da-Costa and Trevenzoli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dietary patterns, as the Mediterranean (n-3 series enriched) are linked to better physiological parameters decreasing the outcome of several types of diseases, which consists of unsaturated lipids from fish (and olive oil, fruits, vegetables, whole grains and legumes/nuts), impacting on the levels of eCBs; they are influenced by the content of n-3 series derived from alpha-linolenic acid (ALA, 18:3n-3) and n-6 series (enriched in Western diet) derived from linoleic acid (LA, 18:2n-6), essential polyunsaturated fatty acids (PUFA); both AEA and 2-AG are derived from AA of the n-6 family, while N-docosahexaenoyl-ethanolamine (DHEA) and N-eicosapentaenoyl-ethanolamine (EPEA), are derived from the n-3 PUFAs docosahexaenoic acid (DHA) and eicosapentanoic acid (EPA).