FIGURE 4.

Exercise reverts some of the collateral effects of a sedentary lifestyle, and has the potential to improve metabolic, cardiovascular, and immune parameters, providing a better memory, cognition, and sleep cycle regulation, delaying brain aging and chronic and neurodegenerative pathologies. It is a common belief that most of the reward induced by acute or chronic exercises (reward, nociception, mood behavior, anxiety, and performance) are related to the release of endorphins and eCBs, which interact with multiple opioid (mu, kappa, and delta) and cannabinoid receptors; Irrefutable evidence demonstrate that the ECS is a major player in systemic energy metabolism, inflammation, appetite control, and pleasure (acute anxiolysis, analgesia, antidepressant effects, sedation, and euphoria) of the so-called runner’s high.