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. 2021 Oct 28;9:644375. doi: 10.3389/fcell.2021.644375

FIGURE 2.

FIGURE 2

Tet1 deficiency reduces the complexity of astrocyte morphology. (A) Representative immunostaining images of astrocyte marker Gfap and mature neuron marker NeuN with brain sections containing the hippocampus CA1 region of WT and Tet1 cKO mice. Scale bar, 100 μm. (B–G) Quantification with Imaris software showed that the perimeter (B), the area (C), the volume (D), the process length (E), the total number of intersections (F), the intersection number at distance from soma (G) of astrocyte decreased in Tet1 cKO mice compared to those of Ctrl mice. 5–6 brain sections with the target region were picked up from 3 WT and cKO mice, respectively. Data were presented as mean ± SEM, unpaired t-test; *P < 0.05; **P < 0.01; ***P < 0.001.