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. 2021 Oct 28;12:753477. doi: 10.3389/fimmu.2021.753477

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Copyright © 2021 Kaul, Benej, Mishra, Ahirwar, Yadav, Stanford, Jacob, Denko and Ganju

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Relative abundance of α-ketoglutarate in PBS- and Slit2-treated WT and PyMT mouse BMDMs. (B) Relative abundance of succinic acid in PBS- and Slit2-treated WT and PyMT mouse BMDMs. (C) Ratio of α-ketoglutarate:succinic acid in PBS- and Slit2-treated WT and PyMT mouse BMDMs. (D) Relative abundance of α-ketoglutarate in PBS- and Slit2-treated human BMDMs. (E) Relative abundance of succinic acid in PBS- and Slit2-treated human BMDMs. (F) Ratio of α-ketoglutarate: succinic acid in PBS- and Slit2-treated human BMDMs. Images represent n = 4–6/group. *p < 0.05, assessed by unpaired t-test.