REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit monoclonal antibody to Phospho-Met (Tyr1234/1235) (D26)	Cell Signaling Technologies	Cat#3077; RRID: AB_2143884
Goat polyclonal antibody to Rabbit Immunoglobulins/HRP	Dako	Cat#P0448
Rat monoclonal antibody to PA tag (NZ-1)	FUJIFILM	Cat# 016-25861
Mouse monoclonal antibody to His-tag (OGHis)	Medical & Biological Laboratories	Cat# D291-3; RRID: AB_10597733
Rabbit monoclonal antibody to EEA1 (C45B10)	Cell Signaling Technology	Cat#3288; RRID: AB_2096811
Rabbit monoclonal antibody to LAMP1 (D2D11)	Cell Signaling Technology	Cat#9091; RRID: AB_2687579
Alexa Fluor 488 conjugated-anti-mouse IgG antibody	Thermo Fisher Scientific	Cat#A11029; RRID: AB_138404
Alexa Fluor 594-conjugated anti-rabbit IgG antibody	Thermo Fisher Scientific	Cat#A11037; RRID: AB_2534095
Bacterial and virus strains
E. coli: XL1-blue	Agilent Technologies	Cat#200249
E. coli: NEB Turbo	New England BioLabs	Cat#C2984I
E. coli: BL21-Gold (DE3)	Agilent Technologies	Cat#230132
Chemicals, peptides, and recombinant proteins
soluble ectodomain fragment of human MET (residues 1-931) possessing a C-terminal PA tag	(Mihara et al., 2021)	N/A
PHA66572	Merck	Cat#CDS022535
Hoechst 33258	Dojindo	Cat#H341
ImmunoStar LD reagent	Fujifilm Wako	Cat#296-69901
Experimental models: Cell lines
Human: Expi293F	Thermo Fisher Scientific	Cat#14635
Human: EHMES-1	Dr. Hamada (Ehime University)	N/A
Human: Met-knockout PC9	(Miao et al., 2019)	N/A
Oligonucleotides
PCR primers used for the construction of expression vectors, see Table S1	Eurofins Genomics or Microsynth AG	N/A
Recombinant DNA
pMG-AaLS-wt	(Azuma et al., 2018)	N/A
pMG-AaLS70::71-aMD4	This paper	N/A
pAC-Ptet-AaLS70::71-aMD4	This paper	N/A
pAC-Ptet-AaLS70::71-aMD5	This paper	N/A
pAC-Ptet-AaLS70::71-aML5	This paper	N/A
pAC-Ptet-cpAaLS(L8)	This paper	N/A
pAC-Ptet-AaLS1::154-aMD4	This paper	N/A
pAC-Ptet-AaLS1::154-aMsD4	This paper	N/A
pAC-Ptet-AaLS1::154-aMD5	This paper	N/A
pAC-Ptet-AaLS1::154-aML5	This paper	N/A
pAC-Ptet-AaLS1::154-aMD4ds	This paper	N/A
pAC-Ptet-AaLS1::154-aMD5ds	This paper	N/A
pAC-Ptet-AaLS1::154-aML5ds	This paper	N/A
Software and algorithms
ExPASy ProtParam tool	Expasy	https://www.expasy.org/
PyMOL 2.3	Schrödinger	http://www.pymol.org
Other
Cu TEM grid	TED PELLA INC., USA	Cat#01814-F
Cu 400 mesh	JEOL	Cat#1608