Table 1.
Condition-specific pathways: (A) Common DEGs & pathways between DH vs DHF and DHF vs ND (B) DF—DHF-specific (1 pathway), and (C) DF—ND-specific (11 pathways), and (C) DHF—ND-specific (50 pathways).
| Common DEGs | Common pathways | DHF—ND-specific |
|---|---|---|
| IGF1 | Arginine and proline metabolism | 04350 TGF-beta signaling pathway |
| IFT122 | mTOR signaling pathway | 00480 Glutathione metabolism |
| PDLIM7 | ABC transporters | 00983 Drug metabolism - other enzymes |
| GJA9-MYCBP | Oocyte meiosis | 05010 Alzheimer's disease |
| C10orf67 | Cytosolic DNA-sensing pathway | 00040 Pentose and glucuronate interconversions |
| MRAP2 | RIG-I-like receptor signaling pathway | 00020 Citrate cycle (TCA cycle) |
| IRF3 | Apoptosis | 00670 One carbon pool by folate |
| TMEM74 | Focal adhesion | 02020 Two-component system |
| GS1-103B18.1 | Cell cycle - yeast | 00140 Steroid hormone biosynthesis |
| NLGN2 | Toll-like receptor signaling pathway | 00460 Cyanoamino acid metabolism |
| MORC3 | 00600 Sphingolipid metabolism | |
| GJA9 | DF—DHF-specific | 03050 Proteasome |
| PAQR3 | Complement and coagulation cascades | 04130 SNARE interactions in vesicular transport |
| C7orf49 | 00590 Arachidonic acid metabolism | |
| FGF4 | DF—ND-specific | 04940 Type I diabetes mellitus |
| SIK2 | Renin-angiotensin system | 00071 Fatty acid metabolism |
| CYCSP44 | Glycosphingolipid biosynthesis - lacto and neolacto series | 04270 Vascular smooth muscle contraction |
| CSMD1 | Glycosaminoglycan biosynthesis - chondroitin sulfate | 04950 Maturity onset diabetes of the young |
| SLC7A8 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 05416 Viral myocarditis |
| INSIG2 | Phototransduction | 04330 Notch signaling pathway |
| ATP11B | Glycosaminoglycan biosynthesis - keratan sulfate | 04630 Jak-STAT signaling pathway |
| MBNL1 | Amino sugar and nucleotide sugar metabolism | 00625 Tetrachloroethene degradation |
| DNPEP | Basal cell carcinoma | 04020 Calcium signaling pathway |
| F13B | Lysosome | 00361 gamma-Hexachlorocyclohexane degradation |
| NCAPD2 | N-Glycan biosynthesis | 00591 Linoleic acid metabolism |
| TNFRSF10B | Streptomycin biosynthesis | 00230 Purine metabolism |
| HSH2D | 00830 Retinol metabolism | |
| LOC101927870 | 00363 Bisphenol A degradation | |
| REL | 00290 Valine leucine and isoleucine biosynthesis | |
| GORASP2 | 04520 Adherens junction | |
| MYCBP | 00270 Cysteine and methionine metabolism | |
| DUSP16 | 00770 Pantothenate and CoA biosynthesis | |
| CCDC7 | 00650 Butanoate metabolism | |
| PYCRL | 04920 Adipocytokine signaling pathway | |
| LOC653739 | 05140 Leishmaniasis | |
| ABCA13 | 04640 Hematopoietic cell lineage | |
| 00260 Glycine serine and threonine metabolism | ||
| 00430 Taurine and hypotaurine metabolism | ||
| 03020 RNA polymerase | ||
| 00620 Pyruvate metabolism | ||
| 00970 Aminoacyl-tRNA biosynthesis | ||
| 04621 NOD-like receptor signaling pathway | ||
| 03030 DNA replication | ||
| 00240 Pyrimidine metabolism | ||
| 05414 Dilated cardiomyopathy | ||
| 05142 Chagas disease | ||
| 05310 Asthma | ||
| 05222 Small cell lung cancer | ||
| 00120 Primary bile acid biosynthesis | ||
| 03022 Basal transcription factors |