Figure 6.

Rod degeneration of APP23 mice was evaluated by scotopic ERG at 9 months

(A) Representative response to 1.59E+5 photons/μm² light stimulus of WT (left, blue) and APP23 mice (right, red).

(B) Representative response to 1.06E+6 photons/μm² light stimulus of WT (left, blue) and APP23 mice (right, red).

(C) ERG a-wave amplitude-light intensities relations of WT (n = 6) and APP23 (n = 7) mice.

(D and E) APP23 a-wave amplitude was significantly lower than that of WT mice, under 1.59E+5 photons/μm² light stimulus (D) and 1.06E+6 photons/μm² light stimulus (E). Data are represented as mean ± SEM. ∗: p < 0.05, ∗∗: p < 0.01, Student's t test.