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. 2021 Oct 21;24(11):103327. doi: 10.1016/j.isci.2021.103327

Figure 8.

Figure 8

Rod bipolar cells (RBCs), synaptic connections between rods and rod bipolar cells were maintained in APP23 mice at 12 months

(A) There was no difference in PKCα expression in RBC somas or dendrites between APP23 and WT mice at 12 months.

(B–C) Immunostaining of retinal flat mounts from APP23 and WT mice with PKCα at 12 months.

(D) There was no difference in the number of RBC axonal terminals between APP23 and WT mice.

(E) Immunostaining of retinal flat mounts from 12-month-old APP23 and WT mice with CtBP2 (a synaptic ribbon marker) and PKCα.

(F–G) The number of CtBP2 signals in an axon terminal of a rod bipolar cell was maintained in APP23 mice compared with WT mice at 12 months.

(H–I) Histological analysis of the synaptic connection between rods and rod bipolar cells with PKCα, CtBP2, and PSD95 (photoreceptor terminal) on retinal cross sections.

(J) There was no difference in the thickness of the outer plexiform layer (OPL) between APP23 and WT mice at 12 months. Data are represented as mean ± SEM. ns: not significant, Student's t test.